Oh, many times! Scientists make mistakes all the time. This is normal – it’s what humans do. Of course, science is no good unless it’s done exactly right, so we need to check our results many, many times to make sure they are right.
I guess I should get the boring bit out of the way first. You ought to follow the guidelines. Having said that, I don’t always :s! Sometimes it’s because I’m short on time and I think I can do something different. Sometimes it’s because I find a better way of doing something. Luckly, nothing has ever gone really wrong when I’ve not follwoed the guidlines, I’m not sure my boss would be too happy :)!!!
I would always follow guidleines if I thought that not doing so would be dangerous.
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